Benzaldehyde → 2-Chloro-1-phenylethanol

HRID 1858407Notes

Reaction equation

[CH2:1]([Cl:10])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].C(=O)C1C=CC=CC=1>>[C:4]1([CH:2]([OH:3])[CH2:1][Cl:10])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 240Benzaldehyde

HCID 107572-Chloroacetophenone

Product 1

HCID 928982-Chloro-1-phenylethanolYield 103.3%

Procedure

The procedure of Example 10 was followed using 0.773 g (5 mmol) of phenacyl chloride in lieu of benzaldehyde, to give 809 mg of 1-phenyl-2-chloroethanol as an oil. Conversion rate: 97.5%; yield 80.4%.

Sources & evidence

ORD record: ord-0ec98237d0c54f00956e56f414521ff6
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06150567

Reaction notes

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