Methanesulfonyl chloride → HCID 18759097, compound

HRID 1858476Notes

Reaction equation

HRID 1858476 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH:8]([CH3:10])[CH3:9])[S:6][CH:7]=1.C(N(C(C)C)CC)(C)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH:8]([C:5]1[S:6][CH:7]=[C:3]([CH2:2][O:1][S:21]([CH3:20])(=[O:23])=[O:22])[N:4]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 105349374-(Hydroxymethyl)-2-Isopropylthiazole

Product 1

HCID 18759097HCID 18759097, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.2 mmol of 4-(hydroxymethyl)-2-isopropylthiazole and 1.3 mmol of diisopropylethylamine in 20 ml of dichloromethane was cooled to -20° C. and treated dropwise with 1.3 mmol of methanesulfonyl chloride. The resulting mixture was stirred for 1 h, quenched with aqueous citric acid, separated, dried over Na2SO4, and concentrated in vacuo to provide the desired compound.

Workup

  1. customquenched with aqueous citric acid
  2. customseparated
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f7e1a5b9e24d40a8bce93fea345bf684
Source dataset
uspto-grants-2000_11
Patent number
US06150530

Reaction notes

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