Hydrochloric Acid → HCID 178513873, compound

Participants

Reaction Steps

To a mixture of ethyl 2-mercapto-4-thiazole acetate (203 mg) in ammonia solution (25%) (1.0 ml) was added ammonium chloride (5.3 mg) at room temperature. After stirring at the same temperature for 8 hours, the solution was poured into a mixture of tetrahydrofuran and saturated sodium chloride solution, and adjusted to pH 3.0 with 1N-hydrochloric acid and extracted with tetrahydrofuran twice. The combined organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure to give 2-mercapto-4-thiazole acetamide (171 mg).

Provenance & Evidence