Hydrochloric Acid → HCID 178513873, compound

HRID 1858503Notes

Reaction equation

HRID 1858503 reaction equation
[SH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10]CC)=O)[N:6]=1.[Cl-].[NH4+:14].[Cl-].[Na+].Cl>N.O1CCCC1>[SH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH2:14])=[O:10])[N:6]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 25517Ammonium ChlorideHCID 178470768HCID 178470768, compound

Product 1

HCID 178513873HCID 178513873, compoundYield 990.5%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of ethyl 2-mercapto-4-thiazole acetate (203 mg) in ammonia solution (25%) (1.0 ml) was added ammonium chloride (5.3 mg) at room temperature. After stirring at the same temperature for 8 hours, the solution was poured into a mixture of tetrahydrofuran and saturated sodium chloride solution, and adjusted to pH 3.0 with 1N-hydrochloric acid and extracted with tetrahydrofuran twice. The combined organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure to give 2-mercapto-4-thiazole acetamide (171 mg).

Workup

  1. extractionextracted with tetrahydrofuran twice
  2. washThe combined organic layer was washed with saturated sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-83966456456547d98af77c30b9028af3
Source dataset
uspto-grants-2000_11
Patent number
US06150351

Reaction notes

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