HRID1858720

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22126520

未命名化合物

反应SMILES：CC(C)(C)OC(=O)N1C2CCC1C(O)C(c1ccc(F)cc1)C2

HCID54217560

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)N1C2CCC1C(OCc1cc(OCc3ccccc3)c3ccccc3c1)C(c1ccc(F)cc1)C2

HCID86604443

未命名化合物

PROCEDURE

实验过程

Alkylation of tert-butyl (1RS,2RS,3RS,5RS)-3-(4-fluoro-phenyl)-2-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylate with 1-benzyloxy-3-chloromethyl-naphthalene (Example 19) analogously to the procedure described in Example 1 (g) yielded tert-butyl (1RS,2RS,3RS,5SR)-2-(4-benzyloxy-naphthalen-2-yl-methoxy)-3-(4-fluoro-phenyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylate as a colourless solid; MS: 568 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2fe7d942336c4daa97eba69ff4ed7f0f
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06150526
来源说明: uspto-grants-2000_11

反应SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:14][CH:13]3[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:10]([CH2:11][CH2:12]3)[CH:9]2[OH:23])=[CH:4][CH:3]=1.[CH2:24]([O:31][C:32]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[C:34]([CH2:42]Cl)[CH:33]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([O:31][C:32]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:35]=[C:34]([CH2:42][O:23][CH:9]2[CH:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:14][CH:13]3[N:15]([C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[CH:10]2[CH2:11][CH2:12]3)[CH:33]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1