Hydrochloric Acid → HCID 22127778, compound

HRID 1858751Notes

Reaction equation

HRID 1858751 reaction equation
[C:1]([C:9]1[CH:10]=[C:11]([CH:34]=[CH:35][CH:36]=1)[CH2:12][O:13][CH:14]1[CH:19]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:37]>CO>[ClH:37].[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH:19]2[CH2:18][CH2:17][NH:16][CH2:15][CH:14]2[O:13][CH2:12][C:11]2[CH:10]=[C:9]([C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[O:8])[CH:36]=[CH:35][CH:34]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86604453HCID 86604453, compound

Product 1

HCID 22127778HCID 22127778, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 22(l), from tert-butyl (3RS,4RS)-3-(3-benzoyl-benzyloxy)-4-(4-fluoro-phenyl)-piperidine-1-carboxylate by cleavage of the BOC group with hydrogen chloride in methanol there was obtained [3-[(3RS,4RS)-4-(4-fluoro-phenyl)-piperidin-3-yloxymethyl]-phenyl]-phenyl-methanone hydrochloride (1:1) in the form of colourless crystals; MS: 390 (M+H)+.

Sources & evidence

ORD record
ord-2ed1adf2d6de4418a1c6aabae0c70cb2
Source dataset
uspto-grants-2000_11
Patent number
US06150526

Reaction notes

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