Methylparaben → HCID 22127420, compound

HRID 1858764Notes

Reaction equation

HRID 1858764 reaction equation
ClCC1C=CC(O[CH2:10][O:11][CH2:12][CH2:13][Si:14]([CH3:17])([CH3:16])[CH3:15])=CC=1.O[C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][CH:20]=1>>[CH3:15][Si:14]([CH3:17])([CH3:16])[CH2:13][CH2:12][O:11][CH2:10][C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7456MethylparabenHCID 15197533(2-{[4-(Chloromethyl)phenoxy]methoxy}ethyl)(trimethyl)silane

Product 1

HCID 22127420HCID 22127420, compound

Procedure

The 1-chloromethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-benzene used at the alkylating agent was prepared in analogy to Example 5(a)-(c) from methyl 4-hydroxybenzoate by introducing the SEM group to give methyl 4-(2-trimethylsilanylethoxymethyl)-benzoate. Subsequent reduction with lithium aluminium hydride gave [4-(2-trimethylsilanylethoxy-methoxy)-phenyl]-methanol and chlorination of this gave 1-chlormethyl-4-(2-trimethylsilanyl-ethoxymethoxy)-benzene as a colourless oil; MS: 272 (M)+.

Workup

  1. additionby introducing the SEM group

Sources & evidence

ORD record
ord-e267c8b846474f8db1a720e4d2accd0d
Source dataset
uspto-grants-2000_11
Patent number
US06150526

Reaction notes

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