Hydrochloric Acid → HCID 22127740, compound

HRID 1858822Notes

Reaction equation

HRID 1858822 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([O:6][CH2:7][C:8]1[N:9]=[N:10][N:11]([CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH:14]2[O:26][CH2:27][C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=2)[CH:12]=1)=[O:5].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:41]=[CH:40][CH:39]=[CH:38][C:3]=1[C:4]([O:6][CH2:7][C:8]1[N:9]=[N:10][N:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH:14]2[O:26][CH2:27][C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=2)[CH:12]=1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54114624HCID 54114624, compound

Product 1

HCID 22127740HCID 22127740, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 136(a), from tert-butyl (3RS,4RS)-4-[4-(2-chloro-benzoyloxymethyl)-[1,2,3]triazol-1-yl]-3-(naphthalen-2ylmethoxy)-piperidine-1-carboxylate by cleavage of the BOC group with hydrogen chloride in methanol there was obtained 1-[(3RS,4RS)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-1H-[1,2,3]triazol-4-ylmethyl 2-chloro-benzoate hydrochloride (1:1) in the form of colourless crystals; MS: 477 (M+H)+.

Sources & evidence

ORD record
ord-cfc84994d41d4a478c82156b1c73c148
Source dataset
uspto-grants-2000_11
Patent number
US06150526

Reaction notes

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