HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22121921, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22121921 | HCID 22121921 | — |
Reaction Steps
To a solution of 1.5 g of homopiperazine in methylene chloride were added triethylamine and 4-bromo-5-chlorosulfonylisoquinoline, and the mixture was stirred at room temperature and after-treated. The crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and further treated as in Example 1 to provide 0.55 g of the objective compound (white crystals).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153608 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-7e039513dbca4380a0eb26302718e1d6 |
| Source note | uspto-grants-2000_11 |