Triethylamine → HCID 22121921, compound

HRID 1858912Notes

Reaction equation

HRID 1858912 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Br:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][C:24]=2[S:26]([Cl:29])(=[O:28])=[O:27])[CH:19]=[N:18][CH:17]=1>C(Cl)Cl>[ClH:29].[ClH:29].[Br:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][C:24]=2[S:26]([N:1]2[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)(=[O:27])=[O:28])[CH:19]=[N:18][CH:17]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 68163Hexahydro-1,4-diazepineHCID 145800584-Bromo-5-isoquinolinesulfonyl chloride

Product 1

HCID 22121921HCID 22121921, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.5 g of homopiperazine in methylene chloride were added triethylamine and 4-bromo-5-chlorosulfonylisoquinoline, and the mixture was stirred at room temperature and after-treated. The crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and further treated as in Example 1 to provide 0.55 g of the objective compound (white crystals).

Workup

  1. additionafter-treated
  2. customThe crude product was purified by silica gel column chromatography (chloroform/methanol=10/1)
  3. additionfurther treated as in Example 1

Sources & evidence

ORD record
ord-7e039513dbca4380a0eb26302718e1d6
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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