2-Methylpiperazine → HCID 22121915, compound

HRID 1858914Notes

Reaction equation

HRID 1858914 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.[Cl:8][S:9]([C:12]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:13]=1[C:14]([CH3:22])=[CH:15][N:16]=[CH:17]2)(=[O:11])=[O:10]>>[ClH:8].[ClH:8].[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][N:6]([S:9]([C:12]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:13]=2[C:14]([CH3:22])=[CH:15][N:16]=[CH:17]3)(=[O:10])=[O:11])[CH2:7]1

Participants

3

Reactant 2

HCID 660572-MethylpiperazineHCID 154871104-Methylisoquinoline-5-sulfonyl chloride

Product 1

HCID 22121915HCID 22121915, compoundYield 122.6%

Procedure

Using 0.60 g of 2-methylpiperazine and 0.49 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.47 g of the objective compound (white crystals).

Sources & evidence

ORD record
ord-d988dc32c3b249feb4b5a0cc5aaa6376
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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