(2S,5R)-1-Boc-2,5-dimethylpiperazine → HCID 70272419, compound

HRID 1858917Notes

Reaction equation

HRID 1858917 reaction equation
C(OC([N:8]1[CH2:13][C@@H:12]([CH3:14])[NH:11][CH2:10][C@@H:9]1[CH3:15])=O)(C)(C)C.[Cl:16][S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:19])=[O:18]>>[ClH:16].[ClH:16].[CH3:15][C@H:9]1[CH2:10][NH:11][C@H:12]([CH3:14])[CH2:13][N:8]1[S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 11745988(2S,5R)-1-Boc-2,5-dimethylpiperazineHCID 154871104-Methylisoquinoline-5-sulfonyl chloride

Product 1

HCID 70272419HCID 70272419, compoundYield 82.8%

Procedure

Using 0.34 g of trans-1-(tert-butoxycarbonyl)-2,5-dimethylpiperazine and 0.64 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.43 g of the objective compound (white crystals).

Sources & evidence

ORD record
ord-60acfc09b9c24031aced920decad53ae
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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