4-Methylisoquinoline-5-sulfonyl chloride → HCID 21948557, compound

HRID 1858919Notes

Reaction equation

HRID 1858919 reaction equation
[CH3:1][CH:2]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.[Cl:9][S:10]([C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[C:15]([CH3:23])=[CH:16][N:17]=[CH:18]2)(=[O:12])=[O:11]>>[ClH:9].[ClH:9].[CH3:1][CH:2]1[CH2:8][CH2:7][N:6]([S:10]([C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[C:15]([CH3:23])=[CH:16][N:17]=[CH:18]3)(=[O:11])=[O:12])[CH2:5][CH2:4][NH:3]1

Participants

3

Reactant 2

HCID 154871104-Methylisoquinoline-5-sulfonyl chlorideHCID 185456175-Methyl-1,4-diazepane

Product 1

HCID 21948557HCID 21948557, compoundYield 77%

Procedure

Using 0.29 g of hexahydro-5-methyl-1H-1,4-diazepine synthesized in accordance with U.S. Pat. No. 3,040,029 and 0.48 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.3 g of the objective compound (white crystals).

Workup

  1. customsynthesized in accordance with U.S

Sources & evidence

ORD record
ord-9f08fe99771749618caf129b1f9c182e
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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