HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylisoquinoline-5-sulfonyl chloride → 6-Fluoro-hexahydro-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Reactant | HCID 22390554 | HCID 22390554 | — |
| Product | 6-Fluoro-hexahydro-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine hydrochloride | HCID 22121968 | 32.7% |
Reaction Steps
Using 0.65 g of 6-fluoro-hexahydro-1H-1,4-diazepine synthesized in accordance with J. Med. Chem., 1990, 33, 142 and 0.72 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.35 g of the objective compound (white crystals).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153608 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-cc6ef00561ec43a78dbf39b7b4c7e375 |
| Source note | uspto-grants-2000_11 |