4-Methylisoquinoline-5-sulfonyl chloride → HCID 22121916, compound

HRID 1858926Notes

Reaction equation

HRID 1858926 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH:10]([CH2:15][CH3:16])[CH2:9]1)=O)(C)(C)C.[Cl:17][S:18]([C:21]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:22]=1[C:23]([CH3:31])=[CH:24][N:25]=[CH:26]2)(=[O:20])=[O:19]>>[ClH:17].[CH2:15]([CH:10]1[CH2:9][NH:8][CH2:14][CH2:13][CH2:12][N:11]1[S:18]([C:21]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:22]=1[C:23]([CH3:31])=[CH:24][N:25]=[CH:26]2)(=[O:19])=[O:20])[CH3:16]

Participants

3

Reactant 2

HCID 154871104-Methylisoquinoline-5-sulfonyl chlorideHCID 221218911,1-Dimethylethyl 3-ethylhexahydro-1H-1,4-diazepine-1-carboxylate

Product 1

HCID 22121916HCID 22121916, compoundYield 34.5%

Procedure

Using 0.68 g of 1-(tert-butoxycarbonyl)-3-ethyl-hexahydro-1H-1,4-diazepine and 0.72 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.38 g of the objective compound (white crystals).

Sources & evidence

ORD record
ord-61d1178f408d48f3954b6546e4942c8b
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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