HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-Fluorophenyl)cyclohexan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane | HCID 12834404 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 4-(4-Fluorophenyl)cyclohexan-1-one | HCID 12834322 | 87% |
Reaction Steps
Hydrochloric acid (0.75 ml) was added to a solution 8-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decane (10 mmole) in methanol-water (2-1,100 ml). After stirring for 2 hr the methanol was removed in vacuo and the residue extracted with methylene chloride. Removal of the methylene chloride in vacuo gave the product as an oil (87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153611 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-dd25edbf01744a259036c73cb7091c89 |
| Source note | uspto-grants-2000_11 |