Hydrochloric Acid → 4-(4-Fluorophenyl)cyclohexan-1-one

HRID 1858933Notes

Reaction equation

HRID 1858933 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:18][CH2:17][C:12]3(OCC[O:13]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.CO>CO.O>[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:10][CH2:11][C:12](=[O:13])[CH2:17][CH2:18]2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 128344048-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Product 1

HCID 128343224-(4-Fluorophenyl)cyclohexan-1-oneYield 87%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Hydrochloric acid (0.75 ml) was added to a solution 8-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decane (10 mmole) in methanol-water (2-1,100 ml). After stirring for 2 hr the methanol was removed in vacuo and the residue extracted with methylene chloride. Removal of the methylene chloride in vacuo gave the product as an oil (87%).

Workup

  1. customwas removed in vacuo
  2. extractionthe residue extracted with methylene chloride
  3. customRemoval of the methylene chloride in vacuo

Sources & evidence

ORD record
ord-dd25edbf01744a259036c73cb7091c89
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

Loading…