HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 22122104 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone | HCID 22122090 | 48% |
Reaction Steps
A solution of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol (3 mmole) in acetone (100 ml) and concentrated HCl (1 ml) was reacted as described in example 25 to give the product (48%, mp: 84-85° C.). Calc'd for C12H12F2O2 : C, 63.72%; H, 5.35%. Found: C, 62.72%; H, 5.24%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153611 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-5900ea93f44047e7ac464e409abfa657 |
| Source note | uspto-grants-2000_11 |