2-(Chloromethyl)quinoline hydrochloride → HCID 178505743, compound

HRID 1858948Notes

Reaction equation

HRID 1858948 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.Cl[CH2:22][C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:9][CH2:10][C@H:11]([N:14]3[CH2:15][CH2:16][N:17]([CH2:22][C:23]4[CH:32]=[CH:31][C:30]5[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=5)[N:24]=4)[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 30838232-(Chloromethyl)quinoline hydrochlorideHCID 178505742HCID 178505742, compound

Product 1

HCID 178505743HCID 178505743, compoundYield 82%

Procedure

This compound was prepared from trans 1-[4-(4-fluorophenyl)-1-cyclohexyl]piperazine (2.4 mmole) and 2-chloromethylquinoline hydrochloride (2.4 mmole) by the method described in Example 45 to give the product (82%, mp 160-162° C.). Calc'd for C26H30FN3.0.2H2O: C, 76.70%; H, 7.53%; N, 10.32% Found: C, 76.68%; H, 7.49%; N, 10.32%.

Sources & evidence

ORD record
ord-9221ee15ada34c38bc7a90f2ed74b37b
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

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