N-(3-methoxyphenyl)piperazine → HCID 12114676, compound

HRID 1858974Notes

Reaction equation

HRID 1858974 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]([CH3:16])[C:13]([OH:15])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Na].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][N:29]([C:2]3[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]([CH2:16][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:13]([OH:15])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=3)[CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 81430N-(3-methoxyphenyl)piperazineHCID 737463HCID 737463, compoundHCID 5360545Sodium

Product 1

HCID 12114676HCID 12114676, compound

Procedure

In a manner similar to Example 3(b), (S)-2-(4-fluoro-benzenesulfonylamino)-propionic acid, sodium salt and 4-(3-methoxy-phenyl)-piperazine were condensed to give the title compound as a pale red-brown solid, mp=137-139° C.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-3c35a6c9e65b402b81bc825b540b2801
Source dataset
uspto-grants-2000_11
Patent number
US06153612

Reaction notes

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