Hydrochloric Acid → 2,5-Dichloroaniline--hydrogen chloride (1/1)

HRID 1858979Notes

Reaction equation

HRID 1858979 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:3]=1[NH2:4].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:3]=1[NH2:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 72622,5-Dichloroaniline

Product 1

HCID 5206502,5-Dichloroaniline--hydrogen chloride (1/1)Yield 179.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 2,5-dichloroaniline (Aldrich, 1.5 g, 9 mmol) in methanol (10 mL) was added methanolic HCl (1M, 30 mL) at 4° C., then the reaction mixture was stirred at 25° C. for 30 minutes. The resulting solution was then evaporated and dried under vacuum to afford 1.6 g of 2,5-dichloroaniline hydrochloride (88% yield).

Workup

  1. customThe resulting solution was then evaporated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-d16377c78be740c39bb41ca9edea1fda
Source dataset
uspto-grants-2000_11
Patent number
US06153604

Reaction notes

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