反应详情

A mixture of 2,5-dichlorophenylcyanamide (1.02 g, 5.5 mmol), 3-ethylaniline mesylate (1.1 g, 5 mmol), and chlorobenzene (15 mL) were combined in a dry round bottom flask equipped with a water cooled condenser under nitrogen and placed in a preheated oil bath (150-160° C.). The reaction mixture was heated for 2 hours. After cooling, the crude reaction product was purified by crystallization from chlorobenzene/diethylether. The resulting crystals were collected by filtration, washed with diethylether, and dried in a vacuum oven (40° C., hours) to yield the title compound, N-(3-ethylphenyl)-N'-(2,5-dichlorophenyl)guanidine mesylate, as a white solid (1.5 g, 75% yield).

1. customwere combined in a dry round bottom flask
2. customequipped with a water cooled condenser under nitrogen
3. customplaced in a preheated oil bath
4. custom(150-160° C.)
5. temperatureThe reaction mixture was heated for 2 hours
6. temperatureAfter cooling
7. customthe crude reaction product
8. customwas purified by crystallization from chlorobenzene/diethylether
9. filtrationThe resulting crystals were collected by filtration
10. washwashed with diethylether
11. customdried in a vacuum oven (40° C., hours)