1-(2-Methoxyphenyl)piperazine → HCID 22115538, compound

HRID 1858991Notes

Reaction equation

HRID 1858991 reaction equation
[C:1]([C:6]1[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:9]([CH3:17])[S:8][C:7]=1[NH:18][C:19]([NH:21][CH2:22][CH2:23]Cl)=[O:20])([O:3][CH2:4][CH3:5])=[O:2].[CH3:25][O:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1.C(N(C(C)C)CC)(C)C>C(#N)C>[C:1]([C:6]1[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:9]([CH3:17])[S:8][C:7]=1[NH:18][C:19]([NH:21][CH2:22][CH2:23][N:36]1[CH2:35][CH2:34][N:33]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[O:26][CH3:25])[CH2:38][CH2:37]1)=[O:20])([O:3][CH2:4][CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 81531DiisopropylethylamineHCID 54005879HCID 54005879, compound

Product 1

HCID 22115538HCID 22115538, compoundYield 63.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of Example 2A (0.60 g, 1.6 mmol), 1-(2-methoxyphenyl)piperazine (0.84 g, 6.5 mmol) and diisopropylethylamine (0.35 mL) in acetonitrile (25 mL) was processed as in Example 1B. Purification of the crude product on silica gel with 2% triethylamine 50% ethyl acetate/hexane provided 0.53 g of the title compound.

Workup

  1. customPurification of the crude product on silica gel with 2% triethylamine 50% ethyl acetate/hexane

Sources & evidence

ORD record
ord-bb71f48a0fc24421989cf3c4ecb980f3
Source dataset
uspto-grants-2000_11
Patent number
US06153614

Reaction notes

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