Phenyl Isothiocyanate → HCID 15481719, compound

HRID 1859010Notes

Reaction equation

HRID 1859010 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:24])([C@H:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[C:25]1([N:31]=[C:32]=[S:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH:31]([C:32]([N:21]1[CH2:20][CH2:19][N:18]([C@H:16]([CH3:17])[C@:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])([OH:24])[CH2:10][N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)[CH2:23][CH2:22]1)=[S:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 15481711HCID 15481711, compound

Product 1

HCID 15481719HCID 15481719, compoundYield 80%

Procedure

The title compound was prepared similarly to example 8 starting from same piperazine derivative 2 and phenylisothiocyanate. The product was obtained as a colorless solid in 80% yield.

Workup

  1. customThe product was obtained as a colorless solid in 80% yield

Sources & evidence

ORD record
ord-36711cab6ed7484783eaebdf405db4f9
Source dataset
uspto-grants-2000_11
Patent number
US06153616

Reaction notes

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