Hydrochloric Acid → HCID 56723947, compound

HRID 1859029Notes

Reaction equation

HRID 1859029 reaction equation
[N:1](OCCC(C)C)=[O:2].Cl.[F:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[C:16](=[O:20])[CH2:15][CH2:14]2>CO>[F:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[C:16](=[O:20])[C:15](=[N:1][OH:2])[CH2:14]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 1365375-Fluoro-1-indanone

Product 1

HCID 56723947HCID 56723947, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

15 ml of isoamyl nitrite and then 7.5 ml of concentrated hydrochloric acid are added dropwise to a solution, heated to 40° C., of 11.2 g of 5-fluoro-1-indanone in 185 ml of methanol. After reaction for 45 minutes at 40° C., the reaction mixture is cooled with ice. A precipitate is formed, which is filtered off and then dried in vacuo, allowing the expected product to be isolated.

Workup

  1. customAfter reaction for 45 minutes at 40° C.
  2. temperaturethe reaction mixture is cooled with ice
  3. customA precipitate is formed
  4. filtrationwhich is filtered off
  5. customdried in vacuo
  6. customto be isolated

Sources & evidence

ORD record
ord-1af286a08e3044d5969f39a50e96e437
Source dataset
uspto-grants-2000_11
Patent number
US06153625

Reaction notes

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