Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 3-{Benzyl-[2-(2-bromophenyl)-2-oxoethyl]amino}propanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | 3-(Benzylamino)propionitrile | HCID 69719 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,2-Dibromo-1-phenylethanone | HCID 569483 | — |
| 생성물 | 3-{Benzyl-[2-(2-bromophenyl)-2-oxoethyl]amino}propanenitrile | HCID 22123215 | — |
반응 단계
A solution of 97.5 g of 2-bromo-α-bromoacetophenone in 200 ml of acetone is poured dropwise, at ambient temperature, into a solution of 61.7 g de N-benzyl-2-cyanoethylamine and 67 ml of diisopropylethylamine in 200 ml of acetone. After stirring for 12 hours, the reaction mixture is evaporated, taken up in ether, washed twice with 500 ml of water each time and dried. After evaporating under reduced pressure, 131.9 g of expected product are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06153640 |
| 출처 데이터셋 | uspto-grants-2000_11 |
| ORD ID | ord-4867d9ab7c3c41749cd527be64aa2e65 |
| 출처 메모 | uspto-grants-2000_11 |