反应详情

温度

5 °C

To a suspension of 2-benzylidene-1,3-indandione (20 g) in methanol (200 ml) was added 30% hydrogen peroxide (19 ml). The suspension was cooled to 5° C. and 1 N sodium hydroxide (2.1 ml) was added dropwise at such a rate as to keep the temperature below 15 ° C. After completed addition, stirring was continued at room temperature for 30 minutes. The mixture was then poured into water (1.2 L). The resulting crystalline precipitate was collected by filtration, washed on the filter with water (3×100 ml) and dried under high vacuum at room temperature for 24 hours, affording 3-phenylspiro[oxirane-2,2'-indan]-1',3'-dione as a yellow solid (17 g).

1. customthe temperature below 15 ° C
2. additionaddition
3. filtrationThe resulting crystalline precipitate was collected by filtration
4. washwashed on the
5. filtrationfilter with water (3×100 ml)
6. customdried under high vacuum at room temperature for 24 hours