Sodium Azide → HCID 11016392, compound

HRID 1859196Notes

Reaction equation

HRID 1859196 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].CS(O[CH2:10][C:11]1[CH:12]=[C:13]([CH:41]=[CH:42][CH:43]=1)[CH2:14][N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([C:24]2[C:25](=[O:40])[NH:26][C:27](=[O:39])[C:28]=2[C:29]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]([CH3:38])[CH:30]=2)=[CH:16]1)(=O)=O>CN(C)C=O>[N:1]([CH2:10][C:11]1[CH:12]=[C:13]([CH:41]=[CH:42][CH:43]=1)[CH2:14][N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([C:24]2[C:25](=[O:40])[NH:26][C:27](=[O:39])[C:28]=2[C:29]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]([CH3:38])[CH:30]=2)=[CH:16]1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 22123287HCID 22123287, compound

Product 1

HCID 11016392HCID 11016392, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium azide (0.144 g, 2.2 mmol) was added to a solution of the product of step b) (0.28 g, 0.5 mmol) in dry dimethylformamide (5 mL). The mixture was stirred at room temperature for 30 min and then partitioned between ethyl acetate and water. The organic phase was washed three times with water and evaporated (with ethanol), to give the crude sub-title product which was used without further purification.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe organic phase was washed three times with water
  3. customevaporated (with ethanol)

Sources & evidence

ORD record
ord-0ba17489723e4683a6c048a377cb17a3
Source dataset
uspto-grants-2000_11
Patent number
US06153641

Reaction notes

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