HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-Bromo-3-(2,3-dihydro-indol-1-ylmethyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Indoline | HCID 10328 | — |
| Reactant | 4-Bromo-3-(bromomethyl)benzonitrile | HCID 11471344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Bromo-3-(2,3-dihydro-indol-1-ylmethyl)-benzonitrile | HCID 22123286 | — |
Reaction Steps
A mixture of 4-bromo-3-bromomethyl-benzonitrile (2.66 g, 9.7 mmol), indoline (1.14 mL, 10.2 mmol) and triethylamine (1.60 mL, 11.5 mmol) was heated at reflux for 18 h in dry tetrahydrofuran (50 mL). The flask was cooled and ether (100 mL) was added. Evaporation gave crude 4-bromo-3-(2,3-dihydro-indol-1-ylmethyl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153641 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-ffc3e5abe42642188546013b39817110 |
| Source note | uspto-grants-2000_11 |