反应详情

温度

97.5 °C

A slurry of the potassium salt of 2-cyanophenol containing potassium chloride was prepared by mixing 2-cyanophenol (13.2 g), potassium hydroxide (6.8 g) and potassium chloride (20 g) in water (10 g). This solution was added to (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (32.8 g) over 5 minutes while maintaining the temperature at 95-100° C. The resulting mixture was stirred at 110° C. for 3 hours. The reaction mixture was mixed with water and toluene and the organic layer separated. The toluene solution contained (E)-methyl 2-[2-(6- (2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (77.7% yield).

1. customwas prepared
2. customthe organic layer separated