Hydrochloric Acid → HCID 10969180, compound

HRID 1859354Notes

Reaction equation

HRID 1859354 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH2:15][S:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=2)[C:10]([O:12]CC)=[O:11])=[CH:5][CH:4]=1.Cl>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH2:15][S:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=2)[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22123590Ethyl 2-(4-methoxyphenyl)-3-(3-methoxyphenylthio)propionate

Product 1

HCID 10969180HCID 10969180, compound

Procedure

A process for preparing a compound of formula (6): ##STR120## characterized in that a compound of formula (1): ##STR121## is reacted with oxalic acid diethyl ester and sodium hydride to produce a compound of formula (2): ##STR122## the resulting compound of formula (2) is reacted with 3-methoxybenzenethiol represented by the formula: ##STR123## to produce a compound of formula (3): ##STR124## the resulting compound of formula (3) is reacted with hydrochloric acid to produce a compound of formula (4): ##STR125## the compound of formula formula (4) is then cyclized to produce a compound of formula (5): ##STR126## and the compound of formula (5) is reacted with methyl iodide in the presence of lithium diisopropylamide to produce the compound of formula (6).

Sources & evidence

ORD record
ord-82612a7dbd9b4ce197ca0363b0deeae1
Source dataset
uspto-grants-2000_11
Patent number
US06153768

Reaction notes

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