HCID 12018620, compound → HCID 69900681, compound

HRID 1859442Notes

Reaction equation

HRID 1859442 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:40])[C:10]1[CH:39]=[CH:38][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:12][CH:11]=1>ClCCl>[ClH:1].[ClH:1].[CH3:40][N:9]([CH3:8])[C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 12018620HCID 12018620, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69900681HCID 69900681, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 ml of 4 M hydrochloric acid/ethyl acetate was added to a solution of (R)-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (171 mg) in dichloromethane (5 ml), and they were stirred for 2 hours. The solvent was evaporated under reduced pressure. The title compound was obtained in the form of a light yellow solid (220 mg, 84%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-39eccaef845d4b20906fc0ced3771b4a
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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