Ether hydrochloride → HCID 69897907, compound

HRID 1859462Notes

Reaction equation

HRID 1859462 reaction equation
[ClH:1].C(OCC)C.[CH2:7]1[O:37][C:36]2[CH:35]=[CH:34][C:11]([CH2:12][CH2:13][N:14]3[CH2:18][CH2:17][C@@H:16]([N:19]4[C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=5[CH2:23][O:22][C:21]5[CH:30]=[CH:31][CH:32]=[CH:33][C:20]4=5)[CH2:15]3)=[CH:10][C:9]=2[O:8]1>ClCCl>[ClH:1].[CH2:7]1[O:37][C:36]2[CH:35]=[CH:34][C:11]([CH2:12][CH2:13][N:14]3[CH2:18][CH2:17][C@@H:16]([N:19]4[C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=5[CH2:23][O:22][C:21]5[CH:30]=[CH:31][CH:32]=[CH:33][C:20]4=5)[CH2:15]3)=[CH:10][C:9]=2[O:8]1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 12018623HCID 12018623, compound

Product 1

HCID 69897907HCID 69897907, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.0 ml of 2 M hydrochloric acid/ethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl) pyrrolidine-3-yl]dibenzo[b,e][1,4]oxazepine (63 mg, 0.15 mmol) in dichloromethane, and they were stirred for 1 hour. The solvent was evaporated under reduced pressure to obtain the title compound in the form of a white solid (62 mg, 91%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-20bd492126b84c969872fbd6155bb136
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

Loading…