Ether hydrochloride → 5-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

HRID 1859477Notes

Reaction equation

HRID 1859477 reaction equation
Cl.C(OCC)C.[Cl:7][C:8]1[CH:34]=[CH:33][C:11]([CH2:12][CH2:13][N:14]([CH2:16][CH2:17][N:18]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][O:21][C:20]3[CH:29]=[CH:30][CH:31]=[CH:32][C:19]2=3)[CH3:15])=[CH:10][CH:9]=1>>[ClH:7].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:12][CH2:13][N:14]([CH2:16][CH2:17][N:18]2[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][O:21][C:20]3[CH:29]=[CH:30][CH:31]=[CH:32][C:19]2=3)[CH3:15])=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 186256005-[2-[N-(4-chlorophenethyl)-N-methyl-amino]ethyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine

Product 1

HCID 699027135-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride

Procedure

5 ml of 2 M hydrochloric acid/ethyl ether was added to 5-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine (282 mg, 0.70 mmol), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure. The obtained residue was recrystallized from a solvent mixture of dichloromethane and ethyl ether to obtain the title compound in the form of light green crystals (163 mg, 87%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe obtained residue was recrystallized from a solvent mixture of dichloromethane and ethyl ether

Sources & evidence

ORD record
ord-1e7f9d9025d948bdbb848ccad8168fe7
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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