HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ether hydrochloride → 5-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Reactant | 5-[2-[N-(4-chlorophenethyl)-N-methyl-amino]ethyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine | HCID 18625600 | — |
| Product | 5-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo [b,e][1,4]oxazepine Hydrochloride | HCID 69902713 | — |
Reaction Steps
5 ml of 2 M hydrochloric acid/ethyl ether was added to 5-[2-[N-(4-chlorophenethyl)-N-methylamino]ethyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine (282 mg, 0.70 mmol), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure. The obtained residue was recrystallized from a solvent mixture of dichloromethane and ethyl ether to obtain the title compound in the form of light green crystals (163 mg, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528504B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-1e7f9d9025d948bdbb848ccad8168fe7 |
| Source note | uspto-grants-2003_03 |