Ether hydrochloride → 5,11-Dihydro-5-[2-[N-(4-dimethylaminophenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine Dihydrochloride

HRID 1859479Notes

Reaction equation

HRID 1859479 reaction equation
[ClH:1].C(OCC)C.[CH3:7][N:8]([CH3:36])[C:9]1[CH:35]=[CH:34][C:12]([CH2:13][CH2:14][N:15]([CH2:17][CH2:18][N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH2:23][O:22][C:21]3[CH:30]=[CH:31][CH:32]=[CH:33][C:20]2=3)[CH3:16])=[CH:11][CH:10]=1>>[ClH:1].[ClH:1].[CH3:36][N:8]([CH3:7])[C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][N:15]([CH2:17][CH2:18][N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH2:23][O:22][C:21]3[CH:30]=[CH:31][CH:32]=[CH:33][C:20]2=3)[CH3:16])=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 186255985,11-dihydro-5-[2-[N-(4-dimethylaminophenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 186256175,11-Dihydro-5-[2-[N-(4-dimethylaminophenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine Dihydrochloride

Procedure

5 ml of 2 M hydrochloric acid/ethyl ether was added to 5,11-dihydro-5-[2-[N-(4-dimethylaminophenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine (184 mg, 0.46 mmol), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure to obtain the title compound in the form of light green crystals (194 mg, 89%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-83ca36dd695c42d0993c8104b449e95b
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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