Ether hydrochloride → HCID 18625625, compound

HRID 1859480Notes

Reaction equation

HRID 1859480 reaction equation
[ClH:1].C(OCC)C.[CH3:7][N:8]([CH3:36])[C:9]1[CH:10]=[C:11]([CH:33]=[CH:34][CH:35]=1)[CH2:12][CH2:13][N:14]([CH2:16][CH2:17][N:18]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[CH2:22][O:21][C:20]2[CH:29]=[CH:30][CH:31]=[CH:32][C:19]1=2)[CH3:15]>>[ClH:1].[ClH:1].[CH3:36][N:8]([CH3:7])[C:9]1[CH:10]=[C:11]([CH:33]=[CH:34][CH:35]=1)[CH2:12][CH2:13][N:14]([CH2:16][CH2:17][N:18]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[CH2:22][O:21][C:20]2[CH:29]=[CH:30][CH:31]=[CH:32][C:19]1=2)[CH3:15]

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 18625580HCID 18625580, compound

Product 1

HCID 18625625HCID 18625625, compound

Procedure

5 ml of 2 M hydrochloric acid/ethyl ether was added to 5,11-dihydro-5-[2-[N-(3-dimethylaminophenethyl)-N-methylamino]ethyl]dibenzo[b,e][1,4]oxazepine (296 mg, 0.74 mmol), and they were stirred for 1 hour. The solvent was evaporated under reduced pressure to obtain the title compound in the form of light green crystals (285 mg, 81%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8130328ddefc465eb9dae0456438139a
Source dataset
uspto-grants-2003_03
Patent number
US06528504B2

Reaction notes

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