反应详情

Chemical Transformation of 24 to 11 through Oxidation with Iodine (Scheme 1): A solution of 24 (5 mg, 0.013 mmol) in 0.5 mL of dry nitromethane was treated with iodine (10 mg, 0.040 mmol) at room temperature with stirring for 1 day (monitor by TLC). At completion the reaction mixture was applied to TLC separation (ethyl acetate:petroleum ether=1:4 v/v for the first development then 1:1 for a second development), and 2 mg of a yellow solid was obtained (yield: 30%), with 1H-NMR and MS data consistent with those of compound 11.

1. customAt completion the reaction mixture was applied to TLC separation (ethyl acetate