反应详情

2,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide (prepared in Example OO-1; 9.4 g, 34 mmol) was dissolved in MeOH (30 mL) and treated with 7% aqueous potassium carbonate solution. The reaction mixture was stirred overnight at room temperature. The reaction was diluted with water (30 mL) and extracted with EtOAc (3×50 mL). The organic layer was washed with saturated NaHCO3 solution and brine, dried (MgSO4), and concentrated. The crude product was used further without any purification. MS(APCI): 181 (M+H).

1. extractionextracted with EtOAc (3×50 mL)
2. washThe organic layer was washed with saturated NaHCO3 solution and brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe crude product was used further without any purification