5-Isopropyl-2-nitro-4-thiocyanato-phenylamine → 4-Isopropyl-5-thiocyanato-benzene-1,2-diamine

HRID 1859559Notes

Reaction equation

HRID 1859559 reaction equation
[CH:1]([C:4]1[C:5]([S:14][C:15]#[N:16])=[CH:6][C:7]([N+:11]([O-])=O)=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2].[H][H]>[Ni].C1COCC1>[CH:1]([C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH2:11])=[CH:6][C:5]=1[S:14][C:15]#[N:16])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 225729135-Isopropyl-2-nitro-4-thiocyanato-phenylamineHCID 178418361HCID 178418361, compound

Product 1

HCID 225728964-Isopropyl-5-thiocyanato-benzene-1,2-diamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine (prepared in Example QQ-1; 7.83 g, 33 mmol) was hydrogenated using Raney nickel (2 g) and THF (100 mL) in the presence of hydrogen (50 psi) as described in General Method 3. MS(APCI): 208(M+H).

Sources & evidence

ORD record
ord-79752caef4654db1bccaed1bfa87f387
Source dataset
uspto-grants-2003_03
Patent number
US06528510B1

Reaction notes

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