Pyridine → 6-tert-Butyl-5-(toluene-4-sulfonylsulfanyl)-1H-indole-2-carboxylic Acid Ethyl Ester

HRID 1859572Notes

Reaction equation

HRID 1859572 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([SH:15])=[C:10]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:9]=2)=[O:5])[CH3:2].N1C=CC=CC=1.[S:26](Br)([C:29]1[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=1)(=[O:28])=[O:27].C(Cl)(Cl)(Cl)Cl>CCOC(C)=O>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([S:15][S:26]([C:29]1[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=1)(=[O:28])=[O:27])=[C:10]([C:16]([CH3:18])([CH3:17])[CH3:19])[CH:9]=2)=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 1049PyridineHCID 5943Carbon TetrachlorideHCID 101308854-Methylbenzene-1-sulfonyl bromideHCID 697360196-tert-Butyl-5-mercapto-1H-indole-2-carboxylic acid ethyl ester

Product 1

HCID 536774156-tert-Butyl-5-(toluene-4-sulfonylsulfanyl)-1H-indole-2-carboxylic Acid Ethyl Ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to General Method 15 using (6-tert-Butyl-5-mercapto-1H-indole-2-carboxylic acid ethyl ester (prepared in Example AAA), pyridine, tosyl bromide, carbon tetrachloride, and EtOAc.

Sources & evidence

ORD record
ord-f568c7c1f2fd43d985514c0ad0510341
Source dataset
uspto-grants-2003_03
Patent number
US06528510B1

Reaction notes

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