Methanol → HCID 17101926, compound

HRID 1859666Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11](F)=[C:10]([N+:15]([O-:17])=[O:16])[CH:9]=1)=[O:6].[Na].[CH3:23][OH:24]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:24][CH3:23])=[C:10]([N+:15]([O-:17])=[O:16])[CH:9]=1)=[O:6]

Participants

Reactant 3

HCID 887Methanol

HCID 3349692HCID 3349692, compound

HCID 5360545Sodium

Product 1

HCID 17101926HCID 17101926, compound

Procedure

Prepared according to the procedure described for Example 10, Step A from 3,4-dichloro-N-(3-nitro-4-fluorophenyl)-benzamide from Example 22, Step A (5.2 g, 20 mmol) and sodium (1.3 g, 57 mmol) using methanol in place of ethanol to afford the product (5.8 g); m.p. 215-218° C. after chromatography on silica gel in dichloromethane/methanol 99:1.

Workup

customPrepared

Sources & evidence

ORD record: ord-e37ebbd1b8ce4befa550322857cf9398
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528528B2

Reaction notes

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