3,5-Dichlorophenyl isothiocyanate → HCID 53815690, compound

HRID 1859704Notes

Reaction equation

HRID 1859704 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:10][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Cl:19][C:20]1[CH:21]=[C:22]([N:27]=[C:28]=[S:29])[CH:23]=[C:24]([Cl:26])[CH:25]=1>>[Cl:19][C:20]1[CH:21]=[C:22]([NH:27][C:28](=[S:29])[NH:1][C:2]2[CH:3]=[C:4]([NH:10][C:11](=[O:18])[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:5]=[CH:6][C:7]=2[O:8][CH3:9])[CH:23]=[C:24]([Cl:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1387763,5-Dichlorophenyl isothiocyanateHCID 18626083HCID 18626083, compound

Product 1

HCID 53815690HCID 53815690, compoundYield 81.1%

Procedure

Prepared according to the procedure described for Example 78 using N-(3-amino-4-methoxyphenyl)-benzamide from Example 21 (0.88 g, 3.62 mmol) and 3,5-dichlorophenyl isothiocyanate (0.739 g, 3.62 mmol). Filtration without trituration afforded the product (1.31 g); m.p. 194-195° C.

Workup

  1. customPrepared
  2. filtrationFiltration without trituration

Sources & evidence

ORD record
ord-c9070dfc578b49ceb478ffbdeed70205
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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