1-Isothiocyanato-3-(trifluoromethyl)benzene → 3,4-Dichloro-N-{4-fluoro-3-[3-(3-trifluoromethylphenyl)-thioureido]-phenyl}-benzamide

HRID 1859723노트

반응식

HRID 1859723 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]([NH2:15])[CH:9]=1)=[O:6].[F:20][C:21]([F:32])([F:31])[C:22]1[CH:23]=[C:24]([N:28]=[C:29]=[S:30])[CH:25]=[CH:26][CH:27]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[C:10]([NH:15][C:29]([NH:28][C:24]2[CH:25]=[CH:26][CH:27]=[C:22]([C:21]([F:20])([F:31])[F:32])[CH:23]=2)=[S:30])[CH:9]=1)=[O:6]

참가 물질

3

반응물 2

HCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzeneHCID 167738583,4-Dichloro-N-(3-amino-4-fluorophenyl)-benzamide

생성물 1

HCID 179217883,4-Dichloro-N-{4-fluoro-3-[3-(3-trifluoromethylphenyl)-thioureido]-phenyl}-benzamide수율 46%

실험 절차

Prepared according to the procedure described for Example 60 using 3,4-dichloro-N-(3-amino-4-fluorophenyl)-benzamide from Example 22 (0.69 g, 2.3 mmol) and 3-trifluoromethylphenyl isothiocyanate (0.47 g, 2.3 mmol) to afford the product (0.532 g); m.p. 172-174° C.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-0f9d00e2938841678d3ee4ac570cb19a
출처 데이터셋
uspto-grants-2003_03
특허 번호
US06528528B2

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