HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isothiocyanato-3-(trifluoromethyl)benzene → 3,4-Dichloro-N-{4-fluoro-3-[3-(3-trifluoromethylphenyl)-thioureido]-phenyl}-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isothiocyanato-3-(trifluoromethyl)benzene | HCID 137232 | — |
| Reactant | 3,4-Dichloro-N-(3-amino-4-fluorophenyl)-benzamide | HCID 16773858 | — |
| Product | 3,4-Dichloro-N-{4-fluoro-3-[3-(3-trifluoromethylphenyl)-thioureido]-phenyl}-benzamide | HCID 17921788 | 46% |
Reaction Steps
Prepared according to the procedure described for Example 60 using 3,4-dichloro-N-(3-amino-4-fluorophenyl)-benzamide from Example 22 (0.69 g, 2.3 mmol) and 3-trifluoromethylphenyl isothiocyanate (0.47 g, 2.3 mmol) to afford the product (0.532 g); m.p. 172-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06528528B2 |
| Source dataset | uspto-grants-2003_03 |
| ORD ID | ord-0f9d00e2938841678d3ee4ac570cb19a |
| Source note | uspto-grants-2003_03 |