4-Bromobenzaldehyde → HCID 178515499, compound

HRID 1859803Notes

Reaction equation

HRID 1859803 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:23]3[C:22](=[O:26])[CH2:21][CH2:20][CH2:19][C:18]=3[CH:17]=2)[N:10]=[CH:9]1)=O)(C)(C)C.[Br:27][C:28]1[CH:35]=[CH:34][C:31]([CH:32]=O)=[CH:30][CH:29]=1>[OH-].[K+].CCO>[Br:27][C:28]1[CH:35]=[CH:34][C:31]([CH:32]=[C:21]2[CH2:20][CH2:19][C:18]3[C:23](=[CH:24][CH:25]=[C:16]([O:15][CH2:14][CH2:13][C:11]4[N:10]=[CH:9][NH:8][CH:12]=4)[CH:17]=3)[C:22]2=[O:26])=[CH:30][CH:29]=1

Participants

5

Reactant 2

HCID 707414-BromobenzaldehydeHCID 54451574HCID 54451574, compound

Product 1

HCID 178515499HCID 178515499, compoundYield 52.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14797Potassium HydroxideSolvent

Procedure

According to the method of Example 32, 4-[2-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-imidazole-1-carboxylic acid tert-butyl ester (0.278 g, 0.78 mmol) was reacted with p-bromobenzaldehyde (0.217 g, 1.17 mmol) in 5 mL of 4% KOH in EtOH overnight to afford 0.173 g (51%) of the title compound as a dark cream-colored powder, mp 176-178° C.: CI-MS m/e 423, 425 M++1).

Sources & evidence

ORD record
ord-08e456e7f7f84da3a99fc88a66a9dfb2
Source dataset
uspto-grants-2003_03
Patent number
US06528535B2

Reaction notes

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