Trifluoroacetic acid → HCID 23554371, compound

HRID 1859847Notes

Reaction equation

HRID 1859847 reaction equation
C(OC([NH:8][C@H:9]([C:11]([NH:13][CH:14]1[N:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[C:18]2[CH:27]=[CH:28][CH:29]=[CH:30][C:17]=2[N:16]([CH2:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34])[C:15]1=[O:38])=[O:12])[CH3:10])=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:8][C@H:9]([C:11]([NH:13][CH:14]1[N:20]=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[C:18]2[CH:27]=[CH:28][CH:29]=[CH:30][C:17]=2[N:16]([CH2:31][C:32](=[O:37])[C:33]([CH3:35])([CH3:34])[CH3:36])[C:15]1=[O:38])=[O:12])[CH3:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23554392HCID 23554392, compound

Product 1

HCID 23554371HCID 23554371, compoundYield 93%

Procedure

The title compound was synthesized using the procedure described in Example C-AE, Step C. A solution of 3-[(N-tert-butoxycarbonyl-L-alaninyl)amino]-2,3-dihydro-1-(3,3-dimethyl-2-oxobutyl)-5-(2-pyridyl)-1H-1,4-benzodiazepin-2-one (4.18 g, 8.01 mmol) was treated with TFA (13.6 mL, 176 mmol) to give 3.14 g (93% yield) the title compound as an off-white foam.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-6f79341c35e74dcda71f28a8b0c98aee
Source dataset
uspto-grants-2003_03
Patent number
US06528505B1

Reaction notes

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