Sodium Hydroxide → HCID 18625740, compound

HRID 1859863Notes

Reaction equation

[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][C:33]([CH:36]([O:39][CH3:40])[O:37][CH3:38])=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][C:33]([CH:36]([O:37][CH3:38])[O:39][CH3:40])=[CH:32][CH:31]=3)=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18625734HCID 18625734, compound

Product 1

HCID 18625740HCID 18625740, compoundYield 99.8%

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(4′-dimethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (1.88 g), which is the product of Reference example 11, was reacted with aqueous sodium hydroxide solution (1N, 6.80 ml) and the reaction mixture was treated to give 2-butyl-3-[4-[2-(4′-dimethoxymethylbiphenyl-4-carbonylamino)ethoxy]phenyl]propionic acid (1.78 g) as a pale brown solid.

Workup

additionthe reaction mixture was treated

Sources & evidence

ORD record: ord-0f8f9fe7da64470bb4f92063576f4183
Source dataset: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06528525B1

Reaction notes

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