Sodium Hydroxide → HCID 23694241, compound

Participants

Reaction Steps

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-hydroxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (345 mg), which is the product of Example 44, was reacted with aqueous sodium hydroxide solution (1N, 2.82 ml) and the reaction mixture was treated to afford the crude free acid which was subjected to chromatography on a silica gel thin layer plate using dichloromethane/methanol=10/1 as the eluant. The product was converted to the sodium salt to give the title compound (200 mg) as colorless crystals.

Provenance & Evidence