Sodium Hydroxide → HCID 23694241, compound

HRID 1859873Notes

Reaction equation

HRID 1859873 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[OH:36])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+:38].[Na]>ClCCl.CO>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[OH:36])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O-:8])=[O:7])[CH2:2][CH2:3][CH3:4].[Na+:38]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 18625924HCID 18625924, compound

Product 1

HCID 23694241HCID 23694241, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-hydroxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (345 mg), which is the product of Example 44, was reacted with aqueous sodium hydroxide solution (1N, 2.82 ml) and the reaction mixture was treated to afford the crude free acid which was subjected to chromatography on a silica gel thin layer plate using dichloromethane/methanol=10/1 as the eluant. The product was converted to the sodium salt to give the title compound (200 mg) as colorless crystals.

Workup

  1. additionthe reaction mixture was treated
  2. customto afford the crude free acid which

Sources & evidence

ORD record
ord-f1daf7d54e214f599163c298c0b3e92a
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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